National Taiwan Ocean University Institutional Repository:Item 987654321/38912
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题名: Effect of Taurine on Toxicity of Oxidized Cholesterol and Oxidized Fish Oil in Rats
作者: Yen-Hung Yeh
Ming-Hsiung Chen
Ya-Ting Lee
Hung-Sheng Hsieh
Deng-Fwu Hwang
贡献者: 國立臺灣海洋大學:食品科學系
关键词: rat
taurine
oxidized cholesterol
hepatotoxicity
oxidized fish oil
日期: 2008-06
上传时间: 2016-11-15T07:07:44Z
出版者: Journal of Food and Drug Analysis
摘要: Abstract: Taurine (2-aminoethanesulfonic acid) occurs naturally in food, especially in seafood and meat. The aim of our investigation was to evaluate the effect of dietary taurine on oxidized cholesterol and oxidized fish oil induced toxicity in male Wistar rats. Thirty male wistar rats were fed with diets supplemented with 5% taurine, 2% oxidized cholesterol or 3% oxidized fish oil for 6 weeks. After feeding such diet, taurine could increase the high density lipoprotein-cholesterol (HDL-C) level in plasma, and glu-tathione (GSH) level in plasma, and decrease the activities of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) in plasma, and the levels of low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cho-lesterol (VLDL-C), triglyceride, total cholesterol in plasma, and relative ratios of liver weight to body weight and thiobarbituric acid-reactive substances (TBARS) level in the rat liver caused by oxidized cholesterol and oxidized fish oil. It could reduce the biochemical parameters characteristic in the plasma and rate liver caused by oxidized cholesterol and oxidized fish oil. It was also found that taurine possessed a good recovering effect and a short-term preventing effect from the toxicity of oxidized cholesterol and oxidized fish oil in rats. The results suggest that taurine may play an important role in suppressing effect by oxidized choles-terol and oxidized fish oil induced toxicity in rats.
關聯: 16(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38912
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