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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38611

Title: Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass
Authors: H.-M. Lin
W.-K. Wang
P.-A. Hsiung
S.-G. Shyu
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Keywords: Light-sensitive intelligent
Mesoporous bioactive glass
Photo-controlled
Drug delivery system
Date: 2010
Issue Date: 2016-10-18T08:31:02Z
Publisher: Acta Biomaterialia
Abstract: Abstract: Functionalized mesoporous bioactive glasses (MBG) with photoactive coumarin demonstrates photo-responsive dimerization resulting in reversible gate operation. Coumarin-modified MBG was used as a drug delivery carrier to investigate drug storage/release characteristics using phenanthrene as a model drug. Irradiation with UV light (>310 nm) induced photo-dimerization of the coumarin-modified MBG, which led to the pores’ closing with cyclobutane dimers and trapping of the guest phenanthrene in the mesopores. However, irradiating the dimerized-coumarin-modified MBG with shorter wavelength UV light (∼250 nm) regenerates the coumarin monomer derivative by the photo-cleavage of cyclobutane dimers, such that trapped guest molecules are released from the mesopores. The structural, morphological, textural and optical properties are well characterized by X-ray diffraction, transmission electron microscopy, N2 adsorption/desorption, and UV–visible spectroscopy. The results reveal that the MBG exhibits the typical ordered characteristics of the hexagonal mesostructure. The system demonstrates great potential in light-sensitive intelligent drug delivery systems and disease therapy fields.
Relation: 6(8)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38611
Appears in Collections:[生命科學系] 期刊論文

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