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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38562

Title: Collagen-Hydroxyapatite Microspheres as Carriers for Bone Morphogenic Protein-4
Authors: Yng-Jiin Wang;Feng-Huei Lin;Jui-Sheng Sun, †;Yi-Chau Huang;Shan-Chang Chue;Fu-Yin Hsu
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Date: 2003
Issue Date: 2016-10-11T07:45:05Z
Publisher: Artificial Organs
Abstract: Abstract: The purpose of the current study is to evaluate
the carrier capability of collagen-hydroxyapatite microspheres
to the bone morphogenic proteins (BMP). After
anesthesia, a bone defect (6.0 mm in diameter and 10.0 mm
in depth) was created at the distal femoral condyles of New
Zealand white rabbits. These 10.0 mm3 defects were then
completely filled with the implant materials. After 2, 4, 6,
and 8 weeks, the animals were sacrificed and histological
evaluations were performed. The results showed that when
the defects were left untreated, there was no evidence of
bone formation during the eight-week experimental
period. In the group treated with collagen-hydroxyapatite
microspheres without BMP-4, the defect was filled with
fibrous tissue and inflammatory cells, while active bone formation
with mature marrow tissue formation was evident
in the defect treated with collagen-hydroxyapatite microspheres
containing BMP-4. Collagen-hydroxyapatite
microspheres were expected to be replaced by the regenerated
bone structure as the bone reconstruction and bone
remodelling process occurred. It was apparent that bone
regeneration was influenced by the addition of BMP-4.
Collagen-hydroxyapatite microspheres were good carriers
for bone morphogenic proteins. Key Words:
Collagen—Hydroxyapatite—Microspheres—Bone morphogenic
protein-4—Bone defect.
Relation: 27(2)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38562
Appears in Collections:[生命科學系] 期刊論文

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