National Taiwan Ocean University Institutional Repository:Item 987654321/38560
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 28607/40644
造访人次 : 4807443      在线人数 : 370
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 进阶搜寻

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38560

题名: Fabrication and evaluation of a biodegradable cohesive plug based on reconstituted collagen/γ-polyglutamic acid
作者: Fu-Yin Hsu;Ya-Yun Cheng;Shiao-Wen Tsai;Wei-Bor Tsai
贡献者: 國立臺灣海洋大學:生命科學暨生物科技學系
日期: 2010
上传时间: 2016-10-11T07:30:57Z
出版者: Journal of Biomedical Materials Research Part B: Applied Biomaterials
摘要: Abstract: In the past decade, numerous studies have been devoted to developing natural bioadhesives that have the notable capacity to adhere to wet surfaces. Collagen and γ-polyglutamic acid (γ-PGA) are well-known natural hydrophilic polymers that have both been utilized for their versatility in a wide range of biomedical applications. The aim of this study was the construction and characterization of a cohesive plug composed of γ-PGA and reconstituted collagen fibrils crosslinked with water-soluble carbodiimide. Transmission electron microscopy examinations confirmed that the collagen fibrils in the reconstituted collagen/γ-PGA gel retained their native specific D-period structure. This unique D-pattern structure of collagen plays a major role in hemostasis and is also related to several cellular behaviors. The bonding strength of the reconstituted collagen/γ-PGA adhesive was approximately 42.9 ± 4.0 KPa after 5 min of application and increased to 76.5 ± 15.1 KPa after 24 h. This was much stronger than the fibrin adhesive, whose bonding strength was 30.9 ± 0.2 KPa. Furthermore, the reconstituted collagen/γ-PGA gel degraded gradually after subcutaneous implantation in the backs of rats over a period of 8 weeks, without any severe inflammatory response. On the basis of the histological analysis, fibroblasts migrated into the gel while it degraded, which indicates that the gel is not harmful to cellular activity. Together, these findings demonstrate that using reconstituted collagen with retained D-periodicity as a component of the bioadhesive is a possibly better option to formulate effective adhesiveness and is promising as a scaffold for tissue repair.
關聯: 95B(1)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38560
显示于类别:[生命科學系] 期刊論文

文件中的档案:

档案 描述 大小格式浏览次数
index.html0KbHTML89检视/开启


在NTOUR中所有的数据项都受到原著作权保护.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈