National Taiwan Ocean University Institutional Repository:Item 987654321/38559
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题名: Hyaluronan–cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery
作者: Shiao-Wen Tsai
Ding-Syuan Yu
Shu-Wei Tsao
Fu-Yin Hsu
贡献者: 國立臺灣海洋大學:生命科學暨生物科技學系
关键词: drug delivery
hyaluronan
cisplatin
pectin
alginate
pH-dependent
日期: 2013
上传时间: 2016-10-11T07:26:19Z
出版者: Int J Nanomedicine
摘要: Abstract: Hyaluronan–cisplatin conjugate nanoparticles (HCNPs) were chosen as colon-targeting drug-delivery carriers due to the observation that a variety of malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing cisplatin with a hyaluronan solution, followed by dialysis to remove trace elements. The cells treated with HCNPs showed significantly lower viability than those treated with cisplatin alone. HCNPs were entrapped in Eudragit S100-coated pectinate/alginate microbeads (PAMs) by using an electrospray method and a polyelectrolyte multilayer-coating technique in aqueous solution. The release profile of HCNPs from Eudragit S100-coated HCNP-PAMs was pH-dependent. The percentage of 24-hour drug release was approximately 25.1% and 39.7% in pH 1.2 and pH 4.5 media, respectively. However, the percentage of drug released quickly rose to 75.6% at pH 7.4. Moreover, the result of an in vivo nephrotoxicity study demonstrated that Eudragit S100-coated HCNP-PAMs treatment could mitigate the nephrotoxicity that resulted from cisplatin. From these results, it can be concluded that Eudragit S100-coated HCNP-PAMs are promising carriers for colonspecific drug delivery.
關聯: 8
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38559
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