English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26994/38795
Visitors : 2392547      Online Users : 61
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38528

Title: Silica Nanohybrids Integrated with CuInS2/ZnS Quantum Dots and Magnetite Nanocrystals: Multifunctional Agents for Dual-Modality Imaging and Drug Delivery
Authors: Jen-Chieh Hsu;Chih-Ching Huang;Keng-Liang Ou;Norman Lu;Fu-Der Mai;Jem-Kun Chen;Jia-Yaw Chang
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Date: 2011
Issue Date: 2016-09-08T07:24:50Z
Publisher: Journal of Materials Chemistry
Abstract: Abstract: A strategy is presented for the synthesis of dual-modality and theranostic silica (SiO2) nanohybrids that exert excellent properties for drug delivery vehicles as well as optical and magnetic resonance imaging. SiO2 nanohybrids are composed of CuInS2/ZnS quantum dots and magnetite nanocrystals, with an outside SiO2 shell grafted with poly(ethyleneglycol) and amine groups to provide better biocompatibility and allow subsequent bioconjugation, respectively. The synthesized nanohybrids are of ultra-small size (diameter < 30 nm) and highly monodispersed and stable in aqueous suspension. In vitro results showed that the SiO2 nanohybrids were efficiently taken up by the cells and localized in the intracellular vesicles, emitting strong fluorescence from the cytoplasm and nearby nucleus. It was also demonstrated that SiO2 nanohybrids could be used as a new class of magnetic resonance imaging probes, demonstrating a high spin–spin (T2) relaxivity (r2 = 214 mM−1 s−1). The Pt(IV) anticancer drug, c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2H)2], was used as a model drug to attach to the surface of dual-modality SiO2 nanohybrids by using n-ethyl-N′-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide as the activating agents. The drug readily formed amide linkages with amines on the surface of the SiO2 nanohybrids, resulting in Pt(IV)-conjugated SiO2 nanohybrids. The results reveal that the Pt(IV)-conjugated SiO2 nanohybrids show higher cytotoxicity than the free Pt(IV) anticancer drug, indicating the potential for using the obtained multifunctional SiO2 nanohybrids simultaneously as highly effective dual-modality imaging probes for cancer diagnosis and chemotherapy.
Relation: 48
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38528
Appears in Collections:[生命科學系] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML82View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback