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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38407

Title: Cytoplasmic and nuclear parathyroid hormone-related proteins are opposing prognostic factors in patients with non-small-cell lung cancer who have undergone curative resection
Authors: Chiao-En Wu
Chi-Wei Wang
Wen-Kuan Huang
Cheng-Ta Yang
Yi-Cheng Wu
Ming-Mo Hou
Chia-Hsun Hsieh
Jia-Juan Hsieh
Hsin-Yi Cheng
Todd Hsu
John Wen-Cheng Chang
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Keywords: non-small-cell lung cancer
PTHrP
prognostic factor
Date: 2015
Issue Date: 2016-08-31T07:33:46Z
Publisher: Jpn J Clin Oncol
Abstract: Abstract:
Objective Parathyroid hormone-like related protein was a prognostic factor for non-small-cell lung cancer, but the results were conflicting. The present study was to examine the role of cytoplasmic and nuclear parathyroid hormone-like related protein in patients with non-small-cell lung cancer who have undergone surgical therapy.

Methods The expression of parathyroid hormone-like related protein was examined by immunohistochemical staining in 56 patients with resectable non-small-cell lung cancer. The impact of parathyroid hormone-like related protein expression on cancer recurrence and survival was assessed in combination with clinicopathologic features.

Results Patients with a high expression of cytoplasmic parathyroid hormone-like related protein had a significantly unfavorable prognosis in both disease-free survival (median 16.7 vs. 58.0 months, P = 0.029) and overall survival (median 31.6 months vs. not reached, P = 0.046). In contrast, the patients with high expression of nuclear parathyroid hormone-like related protein had favorable disease-free survival (median 35.1 vs. 19.9 months, P = 0.069) and a significantly better overall survival (median not reached vs. 36.9 months, P = 0.033). There was no correlation between the expression of cytoplasmic and nuclear parathyroid hormone-like related protein (P = 1.00). Furthermore, multivariate analysis using a Cox regression model confirmed that high expression of cytoplasmic parathyroid hormone-like related protein (disease-free survival, hazard ratio: 1.973, P = 0.079; overall survival, hazard ratio: 2.461, P = 0.067) and nuclear parathyroid hormone-like related protein (disease-free survival, hazard ratio: 0.436, P = 0.029; overall survival, hazard ratio: 0.375, P = 0.018) were independently prognostic factors for disease-free survival and overall survival.
Relation: 45(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38407
Appears in Collections:[生命科學系] 期刊論文

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