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Title: Response to sorafenib in a patient with metastatic xp11 translocation renal cell carcinoma
Authors: Hou MM
Hsieh JJ
Chang NJ
Huang HY
Wang HM
Chuang CK
Hsu T
Chang JW.
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Date: 2010
Issue Date: 2016-08-31T07:01:57Z
Publisher: Clinical Drug Investigation
Abstract: Abstract: Sorafenib, a multikinase inhibitor of tumour-cell proliferation and angiogenesis, has been shown to have a role in the treatment of metastatic renal cell carcinoma (RCC). Xp11 translocation carcinoma is a rare subtype of RCC. We report an 18-year-old male patient with metastatic Xp11 translocation RCC who was responsive to sorafenib treatment. Six weeks after commencement of treatment with sorafenib, a CT scan of the patient showed increased central necrosis of the kidney mass and para-aortic lymph nodes as well as regression of the lung and pleural masses. The patient had a progression-free survival of 12 months, and overall survival of 15 months. The most severe adverse effects were grade 3 dermatitis and grade 3 anaemia. This case has demonstrated for the first time that sorafenib is active against Xp11 translocation RCC.
Relation: 30(11)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38401
Appears in Collections:[生命科學系] 期刊論文

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