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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38335

Title: Co-induction of hepatic IGF-1 and progranulin mRNA by growth hormone in tilapia (Oreochromis mossambicus)
Authors: Mark Hung-Chih Chen
Yen-Hsing Li
Yvonne Chang
Shao-Yang Hu
Hong-Yi Gong
Gen-Hwa Lin
Thomas Chen
Jen-Leih Wu
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: ZebraWsh
Growth hormone
Date: 2007
Issue Date: 2016-08-25T08:20:20Z
Publisher: General and Comparative Endocrinology
Abstract: Abstract: Steatohepatitis has recently been increasing as a cofactor influencing the progression of fibrosis, cirrhosis, adenoma and carcinoma in liver; however, the mechanisms by which it contributes to liver injury remain uncertain. We induced steatohepatitis in zebrafish embryos using thioacetamide (TAA). TUNEL assay revealed significant increasing of apoptosis in liver after 5 days post fertilization and the increasing of apoptosis was observed to be associated with the up-regulation of apoptotic genes such as, bad, bax, P-38a, caspase-3 and 8, and JNK-1. Histological sections by oil red O stain showed the accumulation of fatty droplets which causes the pushing of the nucleus towards one side. Up-regulation of steatosis markers such as, ACC, adiponectin, PTL, CEBP- alpha and beta, SREBP-1 was also observed. Furthermore, the elevation of glutathione peroxidase in TAA treated embryos indicated that TAA induces lipid peroxidation which leads to causes liver damage. Zebrafish has already been considered as a good human disease model and in this context; TAA-treated zebrafish may serve as a good animal model to study the molecular pathogenesis of steatohepatitis. Moreover, non-availability of specific drugs to prevent steatohepatitis, this animal model may serve as a powerful preclinical platform to study the therapeutic strategies and for evaluating chemoprevention strategies for this disease.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38335
Appears in Collections:[水產養殖學系] 期刊論文

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