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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37776

Title: Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery
Authors: Fu-Yin Hsu;Ding-Syuan Yu;Chun-Chiang Huang
Contributors: 國立台灣海洋大學:生命科學系
Date: 2013-02
Issue Date: 2016-05-09T03:13:41Z
Publisher: Journal of Materials Science: Materials in Medicine
Abstract: Abstract:The purposes of this study were to develop and evaluate calcium pectinate/alginate microspheres (PAMs) and to exploit their pH-sensitive properties for colon-targeted delivery of encapsulated cisplatin. PAMs were prepared using an electrospraying method. The PAMs, as cores, were then coated with Eudragit S100 using a polyelectrolyte multilayer coating technique in aqueous solution. The morphology of the microspheres was observed under scanning electron microscopy. In vitro drug release studies were performed in simulated gastrointestinal fluid, and the results indicated that approximately 5 % of the cisplatin was released from the Eudragit S100-coated PAMs, and 51 % of the cisplatin was released from the uncoated PAMs at 1 h. The release of cisplatin from the Eudragit S100-coated PAMs was more sustained in simulated gastric fluid than in simulated intestinal fluid due to the increased solubility of the coating polymer in media with pH >7.0. Drug release from the Eudragit S100-coated PAMs was best described by the Higuchi’s square root model. From these results, it was concluded that Eudragit S100-coated PAMs are a potential carrier for delivery of cisplatin to the colon.
Relation: 24(2),pp.317-323
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37776
Appears in Collections:[生命科學系] 期刊論文

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