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题名: Response to Sorafenib in a Patient with Metastatic Xp11 Translocation Renal Cell Carcinoma
作者: Ming-Mo Hou;Jia-Juan Hsieh;Nai-Jen Chang;Hsuan-Ying Huang;Hung-Ming Wang;Cheng-Keng Chuang;Todd HsuJohn Wen-Cheng Chang
贡献者: 國立台灣海洋大學:生命科學系
日期: 2010-11
上传时间: 2016-04-11T02:46:53Z
出版者: Clinical Drug Investigation
摘要: Abstract:Sorafenib, a multikinase inhibitor of tumour-cell proliferation and angiogenesis, has been shown to have a role in the treatment of metastatic renal cell carcinoma (RCC). Xp11 translocation carcinoma is a rare subtype of RCC. We report an 18-year-old male patient with metastatic Xp11 translocation RCC who was responsive to sorafenib treatment. Six weeks after commencement of treatment with sorafenib, a CT scan of the patient showed increased central necrosis of the kidney mass and para-aortic lymph nodes as well as regression of the lung and pleural masses. The patient had a progression-free survival of 12 months, and overall survival of 15 months. The most severe adverse effects were grade 3 dermatitis and grade 3 anaemia. This case has demonstrated for the first time that sorafenib is active against Xp11 translocation RCC.
關聯: 30(11),pp.799-804
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37672
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