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Title: Expression of Estrogen Receptors Alfa and Beta mRNA and Alkaline Phosphatase in the Differentiation of Osteoblasts from Elderly Postmenopausal Women: Comparison with Osteoblasts from Osteosarcoma Cell Lines
Authors: Fang-Ping Chen;Todd Hsu;Chin-Hwa Hu;Wen-Der Wang;Li-Fen Teng;Kun-Chuang Wang
Contributors: 國立台灣海洋大學:生命科學系
Date: 2006-12
Issue Date: 2016-04-11T02:02:39Z
Publisher: Taiwanese Journal of Obstetrics and Gynecology
Abstract: Abstract:The presence of ERa and ERb mRNA in osteoblasts supports the involvement of estrogen in human bone formation. The developmental expression of alkaline phosphatase was not correlated to ER mRNA expression during osteoblast differentiation. ER isoforms may have different functions or interact with each other during osteoblast differentiation. Since the expression of ER isoforms is different between postmenopausal women and osteosarcoma cell lines, characteristics of osteosarcoma cell lines may not be suitable as a model for the evaluation of estrogen effects on postmenopausal osteoporosis.
Relation: 45(4),pp.307–312
Appears in Collections:[Department of Life Science] Periodical Articles

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