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Title: Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery
Authors: Yi-Cheng Huanga,Rou-Ying Lia,Jiun-Yu Chenb,Jen-Kun Chen
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Chitosan;Fucoidan,Gentamicin,Nanoparticle,Pulmonary delivery
Date: 2016-03
Issue Date: 2016-03-03T08:11:00Z
Publisher: Carbohydrate Polymers
Abstract: Abstract:Gentamicin (GM), one of the most commonly used aminoglycoside antibiotics, has been used for treating pneumonia; however, the applicability of GM is limited by its bioavailability and toxic side effects. This study used chitosan (CS)/fucoidan (F) nanoparticles (NPs) to develop a nanoformulation for pulmonary delivery of GM, presenting a biphasic release feature. The NPs exhibited a zero-order release of GM for the first 10 h, followed by a sustained release of up to 72 h, attaining a value of 99%. The GM-loaded CS/F NPs provide multiple antimicrobial capabilities against Klebsiella pneumoniae, including the CS and biphasic release of GM. Compared with the intravenous administration of free GM (0.5 mg/kg), the intratracheal administration of GM-loaded CS/F NP (0.27 mg/kg) presented a superior area under the concentration–time curve/minimum inhibitory concentration ratio, indicating the simultaneous improvement of antimicrobial efficacy and elimination of systemic toxicity. These results suggested that CS/F NPs are potential carriers in pulmonary delivery of GM for pneumonia treatment.
Relation: 138,pp.114-122
Appears in Collections:[Department of Food Science] Periodical Articles

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