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http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37347
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| Title: | Effect of Chitosan on Hepatic Drug-Metabolizing Enzymes and Oxidative Stress in Rats Fed Low- and High-Fat Diets |
| Authors: | Hsien-Tsung Yao;Chong-Kuei Lii;Ruey-Hwang Chou;Jia-Hsuan Lin;Hui-Ting Yang;Meng-Tsan Chiang |
| Contributors: | 國立臺灣海洋大學:食品科學系 |
| Date: | 2010-03
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| Issue Date: | 2016-01-21T05:50:23Z
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| Publisher: | Journal of Agricultural and Food Chemistry |
| Abstract: | Abstract:Chitosan is sold worldwide as a lipid-lowering functional food and may be taken with certain medications. To investigate the effect of chitosan on drug-metabolizing enzymes and oxidative stress in the liver, male Wistar rats were fed a low- or high-fat diet with cellulose or chitosan for 4 weeks. A significant decrease in cytochrome P450 (CYP) 3A-catalyzed testosterone 6beta-hydroxylation in liver microsomes was observed in rats fed the chitosan with low- and high-fat diets. The expression of CYP 3A1 and 3A2, however, was suppressed by chitosan in rats fed the low-fat diet only. Furthermore, rats fed the low-fat diet with chitosan had lower hepatic glutathione S-transferase (GST) activity and superoxide dismutase activity and higher total tissue and microsomal lipid hydroperoxides. Hepatic alpha-tocopherol was lower in rats fed the chitosan-containing diet. The results suggest that chitosan is likely to modulate CYP 3A activity and protein expression and GST activity partially in a dietary fat-dependent manner. This change may cause a decrease in the metabolism of drugs catalyzed by these enzymes in liver tissues. Moreover, decrease of alpha-tocopherol level and SOD activity by chitosan partly accounts for the increase of hepatic lipid peroxidation. |
| Relation: | 8(8),pp.5187-5193 |
| URI: | http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37347 |
| Appears in Collections: | [食品科學系] 期刊論文
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