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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37343

Title: Suppressive Effect of the Ethanolic Extract of Adlay Bran on Cytochrome P-450 Enzymes in Rat Liver and Lungs
Authors: Hsien-Tsung Yao;Jia-Hsuan Lin;Meng-Tsan Chiang;Chong-Kuei Lii;Mei-Nin Luo;Wenchang Chiang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: adlay bran;cytochrome P-450;drug-metabolizing enzymes;lutathione-related antioxidant enzymes;rats
Date: 2011-03
Issue Date: 2016-01-21T03:31:00Z
Publisher: Journal of Agricultural and Food Chemistry
Abstract: Abstract:Adlay (Coix lachryma-jobiL. var.ma-yuenStapf) is a grass crop and is reported to protect against various diseases suchas cancer. To investigate the effect of the ethanolic extract of adlay bran (ABE) on drug-metabolizing enzymes and glutathione-related antioxidant enzymes in rats, three groups of eight male SpragueDawley rats each were fed a control diet or a diet containing5 or 10% ABE for 4 weeks. Significant decreases in microsomal cytochrome P-450 (CYP) 1A1-catalyzed ethoxyresorufinO-deethylation, CYP2C-catalyzed diclofenac 4-hydroxylation, CYP2D-catalyzed dextromethorphanO-demethylation, and CYP3A-catalyzed testosterone 6β-hydroxylation in the liver and CYP1A1-catalyzed ethoxyresorufinO-deethylation in the lungs of rats fedABE were observed. Immunoblot analyses also showed decreases of CYP1A1, 1A2, 2C6, 2C11, 2D1, 2E1, 3A1, and 3A2 in the liverand CYP1A1 in the lungs. Furthermore, rats fed the 10% ABE diet had a higher glutathione content and glutathione peroxidase,glutathione reductase, and glutathioneS-transferase activities in the lungs, but such an increase was not noted in the liver. Inhibitionof various CYP-catalyzed enzyme reactions by ABE in rat and human liver microsomes had also been shown. The results of this studyindicate that ABE feeding may suppress CYP enzyme activities and CYP protein expression in the liver and lungs of rats. Moreover,the increase of the antioxidant potential by ABE is tissue-specific.
Relation: 59(8),pp.4306-4314
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37343
Appears in Collections:[食品科學系] 期刊論文

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