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Title: Low Molecular Weight Chitosan Accelerates Glucagon-like Peptide-1 Secretion in Human Intestinal Endocrine Cells via a p38-Dependent Pathway
Authors: Shing Hwa Liu
Ya Wen Huang
Cheng Tien Wu
Chen Yuan Chiu
Meng Tsan Chiang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: chitosan;glucagon-like peptide-1;proglucagon;p38 MAPK;intestine
Date: 2013
Issue Date: 2016-01-21T02:48:12Z
Publisher: J. Agric. Food Chem
Abstract: Abstract:Chitosan is widely employed as a dietary supplement. Several studies have shown that chitosan possesses an antidiabetic effect. An important intestinal incretin hormone, glucagon-like peptide-1 (GLP-1), is also known to contribute to the amelioration of diabetes. This study investigated whether chitosan possesses an ability in GLP-1 synthesis and secretion in human intestinal cells. Low molecular weight chitosan (LMWC) significantly increases GLP-1 secretion in human intestinal endocrine cells (NCI-H716) in a dose-dependent manner. LMWC could also dose-dependently increase the mRNA expression of proglucagon, a GLP-1 precursor, but did not affect prohormone convertase 3 (PC 3) mRNA expression. LMWC effectively increased the phosphorylation of mitogen-activated protein kinases (MAPK)-p38 and c-Jun N-terminal kinases (JNK), but not extracellular-signal-regulated kinases (ERK). An inhibitor of p38, but not JNK and ERK, significantly reversed the LMWC-increased proglucagon expression. Taken together, LMWC accelerates proglucagon expression and GLP-1 secretion through a p38/MAPK-dependent signaling pathway. These findings suggest that LMWC may provide a strategy for diabetes therapy.
Relation: 61(20),pp.4855–4861
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37326
Appears in Collections:[食品科學系] 期刊論文

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