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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37066

Title: Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells
Authors: Chien-Te Chou
Wen-Feng Lin
Zwe-Ling Kong
Shiow-Yi Chen
Deng-Fwu Hwang
Contributors: 國立臺灣海洋大學:食品科學系
NTOU:Department of Food Science
Date: 2013-10
Issue Date: 2016-01-04T02:47:51Z
Publisher: Springer Vienna
Abstract: Abstract:The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.
Relation: pp.811-819
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/37066
Appears in Collections:[食品科學系] 期刊論文

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