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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/36688

Title: A Novel Rat Model Simulating Biliary Atresia after a Kasai Operation
Authors: Jen-Bin Wang;Chinsu Liu;Yi-Chen Yeh;Chia-Pei Liu;Chun-Ju Chang;Cheng-Yen Chen;Taiwai Chin
張君如
Contributors: NTOU:Department of Food Science
國立臺灣海洋大學:食品科學系
Keywords: biliary atresia;fibrosis;Kasai operation;model;rat;alcohol
Date: 2014-02
Issue Date: 2015-05-19T06:44:51Z
Publisher: Journal of Investigative Surgery
Abstract: The mechanisms of liver fibrosis in biliary atresia (BA) after a Kasai operation deserve studying to improve the clinical outcomes. This study aimed to create a rat model simulating BA after a Kasai operation.
METHODS:
We inserted a polyethylene tube (PE10) into the common hepatic duct (CHD) and ligated the common bile duct (CBD) in 30 newborn rats and injected 95% ethanol into IHD at postoperative week-one (POW-1). The PE10 was removed at POW-3. The rats were sacrificed at POW-5. The CBD cystojejunostomy was performed on another 10 rats at POW-5.
RESULTS:
The IHD obliteration and CBD dilatation were noted at POW-3 cholangiography before removal of the PE tube. The gross findings at sacrifice in the rats without cystojejunostomy included biliary fibrosis, CBD cyst, and IHD obliteration. The microscopic findings of the liver were like BA. Seven of the 10 rats with CBD cystojejunostomy were jaundice-free at POW-8. The fibrosis grade at POW-8 of the rats with CBD cystojejunostomy was significantly lower in the jaundice-free rats (Ishak fibrosis score, 3.4 ± 0.9 and 1.5 ± 0.3 in the jaundiced rats and jaundice-free rats, respectively, p < .05).
CONCLUSION:
Based on our study, CBD cystojejunostomy five weeks after CBD ligation with ethanol injection into the IHD in newborn rats can provide a model for investigating mechanisms and treatments of liver fibrosis in BA after a Kasai operation.
Relation: 27(3), pp.183-190
URI: http://ntour.ntou.edu.tw/handle/987654321/36688
Appears in Collections:[食品科學系] 期刊論文

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