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Title: Expression of Hedgehog Signaling Molecules as a Prognostic Indicator of Oral Squamous Cell Carcinoma.
Authors: Yi-Fen Wang;Chun-Ju Chang;Chin-Ping Lin;Shyue-Yih Chang;Pen-Yuan Chu;Shyh-Kuan Tai;Wing-Yin Li;Clifford KS Chao;Yu-Jen Chen
Contributors: NTOU:Department of Food Science
Keywords: oral squamous cell carcinoma;hedgehog;metastasis;prognosis;survival
Date: 2012-11
Issue Date: 2015-05-19T06:44:51Z
Publisher: Head and Neck
Abstract: Background
Recent studies have indicated hedgehog pathway plays a role in carcinogenesis of certain cancers. We investigated the clinical significance of its signaling components, including Sonic hedgehog (Shh), Patched (Ptch), and Gli-1, in oral squamous cell carcinoma (OSCC).

By immunohistochemistry, we determined Shh, Ptch, and Gli-1 expression in surgical specimens from 40 patients with OSCC. The relationship between expression of these molecules and clinicopathologic variables were assessed by chi-square analysis. Statistical difference of survival was compared using log-rank test.

Ptch overexpression was associated with lymphatic metastasis (p = .028). Nuclear Gli-1 overexpression correlated with primary tumor size (p = .001), lymphatic metastasis (p = .011), and tumor recurrence (p = .008). Overexpression of Ptch (p = .020) or Gli-1 (p = .002) in OSCC indicated poor prognosis in the univariate survival analysis.

Our results suggest sonic hedgehog (Shh) pathway plays an important role in OSCC progression and should be considered a potential therapeutic target. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Relation: 34(11), pp.1556-1561
Appears in Collections:[Department of Food Science] Periodical Articles

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