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题名: NM23-H1 Expression of Head and Neck Squamous Cell Carcinoma in Association with the Response to Cisplatin Treatment
作者: Yi-Fen Wang;Chun-Ju Chang*;Jen-Hwey Chiu;Chin-Ping Lin;Wing-Yin Li;Shyue-Yih Chang;Pen-Yuan Chu;Shyh-Kuan Tai;Yu-Jen Chen*
張君如
贡献者: NTOU:Department of Food Science
國立臺灣海洋大學:食品科學系
关键词: Head and neck squamous cell carcinoma (HNSCC);NM23-H1;Metastasis;Cisplatin;Prognosis
日期: 2014-04
上传时间: 2015-05-19T06:44:50Z
出版者: Oncotarget
摘要: We recently reported that low NM23-H1 expression of head and neck squamous cell carcinoma (HNSCC) correlated with poor patients' prognosis. Growing evidence has indicated that high tumor NM23-H1 expression contributes to a good response to chemotherapy. Therefore, we investigated the role of NM23-H1 in susceptibility of HNSCC cells to cisplatin and its clinical significance, as well as the in vitro study for validation was performed. Using immunohistochemistry, we analyzed NM23-H1 expression in surgical specimens from 46 HNSCC patients with cervical metastases receiving surgery and adjuvant chemoradiotherapy. Low tumor NM23-H1 expression correlated with locoregional recurrence of HNSCC following postoperative cisplatin-basedtherapy (p = 0.056) and poor patient prognosis (p = 0.001). To validate the clinical observation and the effect of NM23-H1 on cisplatin cytotoxicity, we established several stable clones derived from a human HNSCC cell line (SAS) by knockdown and overexpression. Knockdown of NM23-H1 attenuated the chemosensitivity of SAS cells to cisplatin, which was associated with reduced cisplatin-induced S-phase accumulation and downregulation of cyclin E1 and A. Overexpression of NM23-H1 reversed these results, indicating the essential role of NM23-H1 in treatment response to cisplatin. NM23-H1 may participate in HNSCC cell responses to cisplatin and be considered a potential therapeutic target.
關聯: 5(17), pp.7392–7405
URI: http://ntour.ntou.edu.tw/handle/987654321/36684
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