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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/33143

Title: Pharmacokinetics of Furazolidone in Orange-spotted Grouper, Epinephelus coioides
Authors: Jiin-Ju Guo;Hong-Nong Chou;I-Chiu Liao
Contributors: 國立臺灣海洋大學:海洋生物科技及環境生態中心
Keywords: Furazolidone;Pharmacokinetics;Grouper
Date: 2007-12-01
Issue Date: 2012-10-19T08:33:57Z
Publisher: Journal of the Fisheries Society of Taiwan
Abstract: abstract:The pharmacokinetics of furazolidone (FZ) was examined in the orange-spotted grouper (Epinephelus coioides) after intravascular, oral and bath administration. FZ contents in blood and tissues were determined by high performance liquid chromatography. The recoveries of the analytical method applied were 102, 102, 94 and 94% for serum, muscle, liver and kidney, respectively. A two-compartment pharmacokinetic model was found in serum through the mean concentrations of FZ, exhibiting a rapid, biphasic decline after an intravascular dose of 0.1 mg/kg at 23℃. The absorption and elimination halflives of FZ in serum were 0.2 and 3.3 h, respectively. A one-compartment model could be observed from the serum concentration of FZ after an oral dose at 50 mg/kg; the elimination half-lives were found 1.4 and 0.8 h at 23 and 30℃, respectively. During a 24-hour bath period, variable temperatures gave significant effects on rate of absorption and elimination of FZ, while different doses showed different peak concentrations and integrated areas under the concentration-time curve. The bioavailabilities of FZ in the oral and bath applications were 0.4 and 26.4%,respectively. FZ was found mainly distributed in the serum and muscle, rather than in the liver or kidney.
Relation: 34(4), pp.369-378
URI: http://ntour.ntou.edu.tw/handle/987654321/33143
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