English  |  正體中文  |  简体中文  |  Items with full text/Total items : 27248/39091
Visitors : 2416332      Online Users : 57
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/28029

Title: Cross-species Functional Conservation and in silico Gene Replacement for HIF Pathways
Authors: Chia-Sheng Chuang;Chih-Chia Chen;Tun-Wen Pai;Chin-Hua Hu;Hao-Teng Chang;Margaret Dah-Tsyr Chang
Contributors: NTOU:Department of Computer Science and Engineering
國立臺灣海洋大學:資訊工程學系
Keywords: HIF (Hypoxia-inducible factor);KEGG (Kyoto Encyclopedia of Genes and Genomes);Orthology;Paralogy;Signaling pathway
Date: 2010-09
Issue Date: 2011-10-21T02:35:18Z
Publisher: The Fourth International Conference on Computational Systems Biology (ISB2010)
Abstract: Abstract:Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role
in adaptive processes to a hypoxic cellular environment for most of organisms. The activation of HIF pathway has significant impacts on gene expression patterns in cancer research and it is important to analyze functional conservation and possible gene replacement within the HIF pathway for cancer therapies. Phylogenomics is a useful tool to identify the relationship among various species. By evaluating the evidence of homologous relationship within cross-species pathways, functional conservation and gene replacement for a specific biological function can be obtained. Mapping orthologous and paralogous genes through a phylogenetic tree onto the conserved pathways indicates a strong homology of function. This study retrieved an initial pathway from the KEGG pathway database, and constructed an ontology table through cross-species comparison. A quantitatively measured HIF pathway was depicted to illustrate suitable simulations of cellular function, and the built-up map discovered all substitutable genes and explored unknown subpathways by employing homologous appearing rates. Novel terminologies of OrthRate and ParaRate are proposed to quantitatively indicate the flexibility of a homologous pathway and to enhance the substitutable possibilities of functional genes. This is the first novel system which can generate homologous biological pathways for various organisms based on orthologous and paralogous gene analyses.
Relation: pp.176-184
URI: http://ntour.ntou.edu.tw/handle/987654321/28029
Appears in Collections:[資訊工程學系] 演講及研討會

Files in This Item:

File Description SizeFormat
index.html0KbHTML328View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback