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题名: Functional pathway mapping analysis for hypoxia-inducible factors
作者: Chia-Sheng Chuang;Tun-Wen Pai;Chin-Hua Hu;Wen-Shyong Tzou;Margaret Dah-Tsyr Chang;Hao-Teng Chang;Chih-Chia Chen
贡献者: NTOU:Department of Computer Science and Engineering
关键词: hypoxia-inducible factor (HIF);hypoxia-response element (HRE);transcription factor (TF);transcription factor binding site (TFBS);KEGG (Kyoto Encyclopedia of Genes and Genomes);cross-species comparison;orthology;paralogy;functional pathway
日期: 2011-06
上传时间: 2011-10-21T02:35:16Z
出版者: BMC Systems Biology
摘要: Abstract:Background Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer cells. Identifying functional conservation across species and discovering conserved regulatory motifs can facilitate the selection of reference species for empirical tests. This paper describes a cross-species functional pathway mapping strategy based on evidence of homologous relationships that employs matrix-based searching techniques for identifying transcription factor-binding sites on all retrieved HIF target genes. Results HIF-related orthologous and paralogous genes were mapped onto the conserved pathways to indicate functional conservation across species. Quantitatively measured HIF pathways are depicted in order to illustrate the extent of functional conservation. The results show that in spite of the evolutionary process of speciation, distantly related species may exhibit functional conservation owing to conservative pathways. The novel terms OrthRate and ParaRate are proposed to quantitatively indicate the flexibility of a homologous pathway and reveal the alternative regulation of functional genes. Conclusion The developed functional pathway mapping strategy provides a bioinformatics approach for constructing biological pathways by highlighting the homologous relationships between various model species. The mapped HIF pathways were quantitatively illustrated and evaluated by statistically analyzing their conserved transcription factor-binding elements.
關聯: 5(S3), pp.1-9
显示于类别:[資訊工程學系] 期刊論文


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