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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27799

Title: Cross-species Comparison for Identifying Orthologous Simple Sequence Repeats of Disease Genes
Authors: Chih-Chia Chen;Tsan-Huang Shih;Chien-Ming Chen;Chin-Hua Hu;Wen-Shyong Tzou;Tun-Wen Pai
Contributors: NTOU:Department of Computer Science and Engineering
Keywords: simple sequence repeat (SSR);Online Mendelian Inheritance in Man (OMIM);HomoloGene;comparative genomics;genetic diseases
Date: 2009
Issue Date: 2011-10-21T02:34:03Z
Publisher: The Third International Symposium on Optimization and Systems Biology (OSB’09)
Abstract: Abstract:Simple sequence repeats (SSRs) have been demonstrated to affect normal gene function to cause different genetic disorders. Several conserved and even partial functional SSR patterns were discovered in inherited orthologous disease genes. To explore a wide range of SSRs in genetic diseases, a system focuses on orthologous SSRs for disease genes through comparative genomics mechanism is constructed in this research. The system is developed by employing the OMIM (Online Mendelian Inheritance in Man) and the NCBI HomoloGene databases as the resources of human genetic diseases and homologous gene information. In addition, The Comparative Genomics for SSR discovery system (CS-SSR) is also adopted for providing annotated SSR information among various model species. By integrating these data resources and data mining technologies, biologists and doctors can retrieve novel and important conserved SSRs information among orthologous disease genes. The proposed system named as Orthologous SSR for Disease Gene (OSDG) is a comprehensive andefficient online tool for discovering conserved SSRs of disease genes and it is freely available at http://osdg.cs.ntou.edu.tw.
Relation: pp.159-167
URI: http://ntour.ntou.edu.tw/handle/987654321/27799
Appears in Collections:[資訊工程學系] 演講及研討會

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