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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27771

Title: Angle-Distance Image Matching Techniques for Protein Structure Comparison
Authors: Chia-Han Chu;Chuan Yi Tang;Cheng-Yin Tang;Tun-Wen Pai
Contributors: NTOU:Department of Computer Science and Engineering
Keywords: protein structure comparison;secondary structure element;angle-distance image;cross-correlatio
Date: 2008-11
Issue Date: 2011-10-21T02:33:57Z
Publisher: Journal of Molecular Recognition
Abstract: Abstract:Proteins that contain similar structural elements often have analogous functions regardless of the degree of sequence similarity or structure connectivity in space. In general, protein structure comparison (PSC) provides a straightforward methodology for biologists to determine critical aspects of structure and function. Here, we developed a novel PSC technique based on angle-distance image (A-D image) transformation and matching, which is independent of sequence similarity and connectivity of secondary structure elements (SSEs). An A-D image is constructed by utilizing protein secondary structure information. According to various types of SSEs, the mutual SSE pairs of the query protein are classified into three different types of sub-images. Subsequently, corresponding sub-images between query and target protein structures are compared using modified cross-correlation approaches to identify the similarity of various patterns. Structural relationships among proteins are displayed by hierarchical clustering trees, which facilitate the establishment of the evolutionary relationships between structure and function of various proteins.Four standard testing datasets and one newly created dataset were used to evaluate the proposed method. The results demonstrate that proteins from these five datasets can be categorized in conformity with their spatial distribution of SSEs. Moreover, for proteins with low sequence identity that share high structure similarity, the proposed algorithms are an efficient and effective method for structural comparison.
Relation: 21(6), pp.442-452
URI: http://ntour.ntou.edu.tw/handle/987654321/27771
Appears in Collections:[資訊工程學系] 期刊論文

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