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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27577

Title: Photoassisted Synthesis of Luminescent Mannose–Au Nanodots for the Detection of Thyroglobulin in Serum
Authors: Chih-Ching Huang Prof.;Yu-Lun Hung;Yen-Chun Shiang;Tai-Yuan Lin Prof.;Yu-Shen Lin;Chao-Tsen Chen Prof.;Huan-Tsung Chang Prof.
Contributors: NTOU:Institute of Optoelectronic Sciences
Keywords: cancer;glycoproteins;gold;luminescence;nanoparticles
Date: 2010-02-01
Issue Date: 2011-10-21T02:32:12Z
Publisher: Chemistry – An Asian Journal
Abstract: Abstract:We have employed mannose-modified gold nanodots (Man–Au NDs) as a luminescence sensor for the detection of the thyroid-cancer marker thyroglobulin (Tg) in homogeneous solutions. The luminescent Man–Au NDs are prepared through the reaction of 2.9 nm-diameter gold nanoparticles (Au NPs) with 11-mercapto-3,6,9-trioxaundecyl-α-D-mannopyranoside (Man-RSH) under the irradiation of a light-emitting diode (LED). We have found that the irradiation enhances the quantum yield (∼11 %), alters the emission wavelength and lifetimes, and shortens the preparation time. A luminescence assay has been developed for Tg based on the competition between Tg and Man–Au NDs for the interaction with the concanavalin A (Con A). Because luminescence quenching of the Man–Au NDs by Con A is inhibited by Tg selectivity, we have obtained a highly sensitive and selective assay for Tg.
Relation: 5(2), pp.334-341
URI: http://ntour.ntou.edu.tw/handle/987654321/27577
Appears in Collections:[生命科學暨生物科技學系] 期刊論文
[光電科學研究所] 期刊論文

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