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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27416

Title: A concise synthesis of honokiol
Authors: Chang-Ming Chen;Yeuk-Chuen Liu
Contributors: NTOU:Department of Food Science
Keywords: Anti-cancer;neolignan;Suzuki coupling
Date: 2009-03-11
Issue Date: 2011-10-21T02:25:18Z
Publisher: Tetrahedron Letters
Abstract: Abstract:A simple synthesis of the natural product honokiol 1 has been developed which proceeds in four steps and provides a 32% overall yield. Suzuki coupling of 4-allyl-2-bromoanisole 3 with 4-hydroxyphenyl boronic acid, followed by allylation, gave 5-allyl-4′-allyloxy-2-methoxy-biphenyl 5. This compound 5 underwent Lewis acid-catalyzed Claisen rearrangement and demethylation in a one-pot reaction which yielded honokiol.
Relation: 50(10), pp.1151–1152
URI: http://ntour.ntou.edu.tw/handle/987654321/27416
Appears in Collections:[食品科學系] 期刊論文

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