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题名: The effects of cholic acid and cyprinol sulfate on liver damage in rats induced by acetaminophen
作者: Yen-Hung Yeh;Jou-Fang Deng;Po-En Liu;Deng-Fwu Hwang
贡献者: NTOU:Department of Food Science
关键词: Cholic acid;Cyprinol sulfate;Bile acid;Acetaminophen;Liver function
日期: 2007-06
上传时间: 2011-10-21T02:24:17Z
出版者: Taiwanese Journal of Agricultural Chemistry and Food Science
摘要: Abstract:To investigate the effects of bile acids and bile alcohols on liver function, male Wistar rats were used as experimental animals in this study. The rats were divided into two sections: the control section (with no acetaminophen being administered) and the experimental section (with acetaminophen being administered). Liver damage was induced in the experimental section by administering acetaminophen to the rats daily (150 mg/kg daily, i.p.), for 4 days. Each of these two sections (experimental and control) was divided once more into four groups of six rats each. Each set of six rats, within each of the two sections, was treated orally, at 3-day intervals, with either saline solution, 10 mg of cholic acid, 20 mg of cholic acid or 10 mg of cyprinol sulfate, respectively. During the 29-day experimental period, the rats were allowed food and drinking water ad libitum. After the acetaminophen had been administered, the AST, ALT, and ALP activity in the rats’ plasma increased significantly. After 29 days, however, the relative ratios of both liver and kidney weight to body weight, concentrations of RBC, hemoglobin and hematocrit in the blood, levels of AST, ALT, ALP, BUN and creatinine in the plasma, as well as the levels of glutathione and thiobarbituric acid-reactive substances (TBARS) in the livers of the rats, did not differ significantly between the control rats and the experimental rats. This indicated that cholic acid and cyprinol sulfate did not ameliorate the damage induced by acetaminophen in the liver function of rats.
關聯: 45, pp.133-141
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