English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26988/38789
Visitors : 2350794      Online Users : 27
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27291

Title: The effects of cholic acid and cyprinol sulfate on liver damage in rats induced by acetaminophen
Authors: Yen-Hung Yeh;Jou-Fang Deng;Po-En Liu;Deng-Fwu Hwang
Contributors: NTOU:Department of Food Science
國立臺灣海洋大學:食品科學系
Keywords: Cholic acid;Cyprinol sulfate;Bile acid;Acetaminophen;Liver function
Date: 2007-06
Issue Date: 2011-10-21T02:24:17Z
Publisher: Taiwanese Journal of Agricultural Chemistry and Food Science
Abstract: Abstract:To investigate the effects of bile acids and bile alcohols on liver function, male Wistar rats were used as experimental animals in this study. The rats were divided into two sections: the control section (with no acetaminophen being administered) and the experimental section (with acetaminophen being administered). Liver damage was induced in the experimental section by administering acetaminophen to the rats daily (150 mg/kg daily, i.p.), for 4 days. Each of these two sections (experimental and control) was divided once more into four groups of six rats each. Each set of six rats, within each of the two sections, was treated orally, at 3-day intervals, with either saline solution, 10 mg of cholic acid, 20 mg of cholic acid or 10 mg of cyprinol sulfate, respectively. During the 29-day experimental period, the rats were allowed food and drinking water ad libitum. After the acetaminophen had been administered, the AST, ALT, and ALP activity in the rats’ plasma increased significantly. After 29 days, however, the relative ratios of both liver and kidney weight to body weight, concentrations of RBC, hemoglobin and hematocrit in the blood, levels of AST, ALT, ALP, BUN and creatinine in the plasma, as well as the levels of glutathione and thiobarbituric acid-reactive substances (TBARS) in the livers of the rats, did not differ significantly between the control rats and the experimental rats. This indicated that cholic acid and cyprinol sulfate did not ameliorate the damage induced by acetaminophen in the liver function of rats.
Relation: 45, pp.133-141
URI: http://ntour.ntou.edu.tw/handle/987654321/27291
Appears in Collections:[食品科學系] 期刊論文

Files in This Item:

There are no files associated with this item.



All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback