English  |  正體中文  |  简体中文  |  Items with full text/Total items : 28611/40652
Visitors : 782985      Online Users : 79
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27251

Title: Genes, Pathways and Invasive Behavior Associated with Mitochondrial Stress on Human Breast Cancer Cells
Authors: Chang CJ;Yin PH;Tseng LM;Chi CW;Wei YH;Lee HC
Contributors: NTOU:Department of Food Science
Date: 2008
Issue Date: 2011-10-21T02:24:07Z
Publisher: The 23th Joint Annual Conference of Biomedical Sciences (Taipei, Taiwan. March 29-30, 2008)
Abstract: Abstract:One of our recent studies revealed that patients with mitochondrial DNA (mtDNA) D-loop mutation and breast cancer had significantly poorer disease-free survival than those without mutation. The aims of this study were to investigate the effects of mitochondrial alterations on cell invasion and nuclear gene expression of breast cancer. To demonstrate the effects of mitochondrial alterations, we approached by interference with mitochondrial transcription (siRNA), inhibit mitochondrial translation, or damage mitochondrial respiration on breast cancer cells. The enhancements of cell migration and invasion were found in cells under mitochondrial stress. Genome-wild gene expression analyses showed identical nuclear encoded genes were simultaneously affected by different kinds of mitochondrial stress. Biological function annotation (by Gene Ontology, KEGG, GenMAPP and NetAffx) and Bonferroni correction test indicated these differentially expressed genes involved in Wnt and Jak-STAT signaling, as well as biological processes of fibrinolysis, angiogenesis, focal adhesion formation, chromatin assembly, intercellular junction assembly and/or maintenance. These findings suggested that mitochondrial stress causes alterations in nuclear gene expression and cell behavior in human cancers.
Relation: Poster no. 699
URI: http://ntour.ntou.edu.tw/handle/987654321/27251
Appears in Collections:[食品科學系] 演講及研討會

Files in This Item:

There are no files associated with this item.

All items in NTOUR are protected by copyright, with all rights reserved.


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback