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|Title: ||Genes, Pathways and Invasive Behavior Associated with Mitochondrial Stress on Human Breast Cancer Cells|
|Authors: ||Chang CJ;Yin PH;Tseng LM;Chi CW;Wei YH;Lee HC|
|Contributors: ||NTOU:Department of Food Science|
|Issue Date: ||2011-10-21T02:24:07Z
|Publisher: ||The 23th Joint Annual Conference of Biomedical Sciences (Taipei, Taiwan. March 29-30, 2008)|
|Abstract: ||Abstract:One of our recent studies revealed that patients with mitochondrial DNA (mtDNA) D-loop mutation and breast cancer had significantly poorer disease-free survival than those without mutation. The aims of this study were to investigate the effects of mitochondrial alterations on cell invasion and nuclear gene expression of breast cancer. To demonstrate the effects of mitochondrial alterations, we approached by interference with mitochondrial transcription (siRNA), inhibit mitochondrial translation, or damage mitochondrial respiration on breast cancer cells. The enhancements of cell migration and invasion were found in cells under mitochondrial stress. Genome-wild gene expression analyses showed identical nuclear encoded genes were simultaneously affected by different kinds of mitochondrial stress. Biological function annotation (by Gene Ontology, KEGG, GenMAPP and NetAffx) and Bonferroni correction test indicated these differentially expressed genes involved in Wnt and Jak-STAT signaling, as well as biological processes of fibrinolysis, angiogenesis, focal adhesion formation, chromatin assembly, intercellular junction assembly and/or maintenance. These findings suggested that mitochondrial stress causes alterations in nuclear gene expression and cell behavior in human cancers.|
|Relation: ||Poster no. 699|
|Appears in Collections:||[食品科學系] 演講及研討會|
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