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|Title: ||Mitochondrial Stress-induced Nuclear Genomic Alterations in Human Cancer Cells|
|Authors: ||Chang CJ;Yin PH;Tseng LM;Chi CW;Wei YH;Lee HC|
|Contributors: ||NTOU:Department of Food Science|
|Issue Date: ||2011-10-21T02:24:02Z
|Publisher: ||The 2nd Conference of Taiwan Society of Mitochondrial Research and Medicine (Taipei, Taiwan. Feb. 16-7, 2008)|
|Abstract: ||Abstract:Mitochondrial genome instability and reduced copy number of mitochondrial DNA (mtDNA) were commonly found in human cancers. However, the phenotypic effects of the mtDNA alterations and the molecular mechanisms by which the mtDNA alterations lead to cancer progression remain to be established. To demonstrate the effects of mitochondrial stress, we approached by interference with mitochondrial transcription (siRNA), deplete mtDNA, inhibit mitochondrial translation, or disrupt mitochondrial respiration on cancer cells. Whole genome expression profiling were revealed that the mitochondrial stress-induced somatic alterations in mtDNA and nuclear DNA. Importantly, genes participated in interleukin signaling, amino acids metabolism and protein modifications were affected by mitochondrial stress. The mechanisms of mitochondrial stress-induced cancer progression are under investigation.|
|Appears in Collections:||[食品科學系] 演講及研討會|
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