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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27159

Title: Effect of degree of deacetylation of chitosan on physicochemical properties and cytotoxicity of chitosan/beta-glycerolphosphate hydrogel
Authors: Min-Lang Tsai;Sun-Ta Wang;Rong-Huei Chen
Contributors: NTOU:Department of Food Science
國立臺灣海洋大學:食品科學系
Keywords: chitosan;degree of deacetylation;physicochemical property;cytotoxicity;chitosan/beta-glycerolphosphate hydrogel
Date: 2009
Issue Date: 2011-10-21T02:23:47Z
Publisher: 9th International Conference of the European Chitin Society (May 23-26 2009, San Servolo Island, Venice, Italy)
Abstract: Abstract:This study we explore that degree of deacetylation (DD) of chitosan affect the physicochemical properties and cytotoxicity of thermosensitive hydrogel based on chitosan/b-glycerolphosphate (C/b-GP). Chitosan with four different DDs (95, 89, 81, and 73%) have been prepared by squid pen. Viscosity of C/b-GP hydrogel system was measured at different temperature. In the measurements of hydrogel that chitosan DD 73% and 81%, the viscosity tended toward arising at 36.5 and 48 oC, respectively. No significant arising tendency was observed in hydrogel that based on chitosan with DD 89%. Scanning electron microscope graphs showed that the hydrogel present a three-dimensional porous structure which acts as the water vapor barrier and is capable of absorbing wound exudate and provides a moist environment when been used as wound dressing. The diverse micro-structure of hydrogel made by different DD of chitosan has also been displayed. Water vapor transmission rate (WVTR) of hydrogel with different DD of chitosan was evaluated over 6 hours. The result indicated that hydrogel based on chitosan DD 81% was significantly higher in WVTR than other formulations while at 11161.9 g m-2 d-1. On the other hand, the cell cytotoxicity of this formulation in human skin fibroblast (CCD-966SK) was measured by MTT assay. The result indicated that C/b-GP hydrogel composed of chitosan which DD greater than 80% were non-toxicity for human skin fibroblast and could enhance its proliferation
URI: http://ntour.ntou.edu.tw/handle/987654321/27159
Appears in Collections:[食品科學系] 演講及研討會

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