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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27144

Title: Antiviral applications of RNAi for coronavirus
Authors: Chang-Jer Wu;Yi-Lin Chan
Contributors: NTOU:Department of Food Science
國立臺灣海洋大學:食品科學系
Keywords: antiviral agent;coronavirus;severe acute respiratory syndrome;short interfering RNAs
Date: 2006-02
Issue Date: 2011-10-21T02:23:44Z
Publisher: Expert Opinion on Investigational Drugs
Abstract: Abstract:Until the appearance of severe acute respiratory syndrome (SARS), caused by the SARS coronavirus (SARS-CoV) in early 2003, coronavirus infection was not considered to be serious enough to be controlled by either vaccination or specific antiviral therapy. It is now believed that the availability of antiviral drugs effective against SARS-CoV will be crucial for the control of future SARS outbreaks. Recently, RNA interference has been successfully used as a more specific and efficient method for gene silencing. RNA interference induced by small interfering RNA can inhibit the expression of viral antigens and so provides a new approach to the therapy of pathogenic viruses. This review provides an overview of current information on coronavirus and the application of small interfering RNA in viral therapeutics, with particular reference to SARS-CoV.
Relation: 15(2), pp.89-97
URI: http://ntour.ntou.edu.tw/handle/987654321/27144
Appears in Collections:[食品科學系] 期刊論文

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