English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26999/38800
Visitors : 2399284      Online Users : 65
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27064

Title: Molecular surface directionality of the DNA-binding protein surface on the earth map
Authors: Wei-Po Lee;Wen-Shyong Tzou
Contributors: NTOU:Institute of Bioscience and Biotechnology
國立臺灣海洋大學:生物科技研究所
Keywords: normal vector, molecular surface, protein-DNA interaction, earth map.
Date: 2006
Issue Date: 2011-10-21T02:22:30Z
Publisher: Genetics and Molecular Biology
Abstract: Abstract:Protein-DNA interactions play a pivotal role in both the transcriptional control and the maintenance of genome integrity, and these are two properties that are closely linked to the development of an organism, differentiation, physiology and to the progression of diseases. Chemical and geometric properties are typically two of the key components in any analysis that aims to understand the precise origin of specificity and elucidate the atomic features of a protein-DNA interface. In this study, we have developed a unique representation of the directionality of the molecular surface of a DNA-binding protein. The stereo-orientation of the normal vector that signifies the geometric properties of a protein surface was projected onto a two-dimensional surface (referred to here as an earth map). We identified considerably diverse patterns of the vector distribution of the protein surface, and besides this, the DNA-contact surface, a subset of an entire protein surface, has also been found to contain diverse patterns. At the same time, the direction of the DNA-contact surface was also tracked onto the earth map on a base-pair basis and distinct intertwining properties particular to the specific family of that DNA-binding protein are revealed.
Relation: 29(2), pp.408-412
URI: http://ntour.ntou.edu.tw/handle/987654321/27064
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML267View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback