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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27054

Title: Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy
Authors: Tzu-Chao Chuang;Jah-Yao Liu;Chi-Tsai Lin;Ya-Ting Tang;Ming-Han Yeh;Su-Chien Chang;Jhy-Wei Li;Ming-Ching Kao
Contributors: NTOU:Institute of Bioscience and Biotechnology
Keywords: HER2/neu;MnSOD;Metastasis;Breast cancers
Date: 2007-09-18
Issue Date: 2011-10-21T02:22:27Z
Publisher: FEBS Letters
Abstract: Abstract:The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185HER2/neu. Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
Relation: 581(23), pp.4443–4449
URI: http://ntour.ntou.edu.tw/handle/987654321/27054
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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