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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27043

Title: Exploiting knowledge ontology and software agents for PPI network analysis
Authors: Wen-Shyong Tzou;Wei-Po Lee;Bingchiang Jeng
Contributors: NTOU:Institute of Bioscience and Biotechnology
Keywords: Protein–protein interaction;Motif analysis;Evolutionary conservation;Gene ontology;Mobile agent;Adaptive computing
Date: 2009-12
Issue Date: 2011-10-21T02:22:25Z
Publisher: Expert Systems with Applications
Abstract: Abstract:One major goal of functional genomics has been to identify and analyze molecular interactions in a cellular context to better understand the underlying design principles and mechanisms. To investigate into a PPI network from both topological and functional points of view, this work proposes a methodology that exploits ontology-based biological knowledge for network analysis. To speed up the procedure, an agent-based framework is also presented for supporting distributed computing. The preliminary results show that through the knowledge obtained from gene ontology, our work in analyzing building blocks of PPI networks can give a higher resolution than that of previous ones. Also our agent-based framework can successfully speed up the task of network analysis in an adaptive manner.
Relation: 36(10), pp.12605–12612
URI: http://ntour.ntou.edu.tw/handle/987654321/27043
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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