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Title: Computed tomography-guided core-needle biopsy specimens demonstrate epidermal growth factor receptor mutations in patients with non-small-cell lung cancer
Authors: C.-M. Chen;J. W.-C. Chang;Y.-C. Cheung;G. Lin;J.-J. Hsieh;T. Hsu;S.-F. Huang
Contributors: NTOU:Institute of Bioscience and Biotechnology
Keywords: computed tomography;EGFR mutation;lung biopsy;lung cancer
Date: 2008
Issue Date: 2011-10-21T02:22:19Z
Publisher: Acta Radiologica
Abstract: Abstract:
Background: Target therapy with a new class of epidermal growth factor receptor (EGFR) inhibitors shows improved clinical response in EGFR gene-mutated lung cancers. Purpose: To evaluate the use of computed tomography (CT)-guided core-needle biopsy specimens for the assessment of EGFR gene mutation in non-small-cell lung cancer (NSCLC). Material and Methods: Seventeen (nine males, eight females) patients with advanced NSCLC were enrolled in this study. All patients underwent CT-guided core-needle biopsy of the lung tumor prior to treatment with the EGFR inhibitor gefitinib. There were no life-threatening complications of biopsy. The specimens were sent fresh-frozen for EGFR mutation analysis and histopathological study. Results: There were 12 (70.6%) EGFR gene mutants and five (29.4%) nonmutants. The objective response rate to gefitinib therapy was 73.3% (11 of 15 patients), with 91.7% (11 of 12 mutants) for the mutant group and 0% for the nonmutant group. Conclusion: CT-guided core-needle biopsy of advanced NSCLC enables the acquisition of sufficient tissue for EGFR gene mutation analysis.
Relation: 49(9), pp.991-994
URI: http://ntour.ntou.edu.tw/handle/987654321/27015
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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