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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27006

Title: Aptamer-Functionalized Nano-Biosensors
Authors: Tai-Chia Chiu;Chih-Ching Huang
Contributors: NTOU:Institute of Bioscience and Biotechnology
Keywords: nanomaterials;aptamers;biosensors;metal ions;proteins;cells
Date: 2009
Issue Date: 2011-10-21T02:22:17Z
Publisher: Sensors
Abstract: Abstract: Nanomaterials have become one of the most interesting sensing materials because of their unique size- and shape-dependent optical properties, high surface energy and surface-to-volume ratio, and tunable surface properties. Aptamers are oligonucleotides that can bind their target ligands with high affinity. The use of nanomaterials that are bioconjugated with aptamers for selective and sensitive detection of analytes such as small molecules, metal ions, proteins, and cells has been demonstrated. This review focuses on recent progress in the development of biosensors by integrating functional aptamers with different types of nanomaterials, including quantum dots, magnetic nanoparticles (NPs), metallic NPs, and carbon nanotubes. Colorimetry, fluorescence, electrochemistry, surface plasmon resonance, surface-enhanced Raman scattering, and magnetic resonance imaging are common detection modes for a broad range of analytes with high sensitivity and selectivity when using aptamer bioconjugated nanomaterials (Apt-NMs). We highlight the important roles that the size and concentration of nanomaterials, the secondary structure and density of aptamers, and the multivalent interactions play in determining the specificity and sensitivity of the nanosensors towards analytes. Advantages and disadvantages of the Apt-NMs for bioapplications are focused.
Relation: 9(12), pp.10356-10388
URI: http://ntour.ntou.edu.tw/handle/987654321/27006
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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