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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/27000

Title: A fused selenium-containing protein with both GPx and SOD activities
Authors: Huijun Yu;Yan Ge;Ying Wang;Chi-Tsai Lin;Jing Li;Xiaoman Liu;Tianzhu Zang;Jiayun Xu;Junqiu Liu;Guimin Luo;Jiacong Shen
Contributors: NTOU:Institute of Bioscience and Biotechnology
Keywords: Bifunctional enzyme;Artificial enzymes;Fusion protein;Glutathione peroxidase;Selenium-containing glutathione transferase;Superoxide dismutase
Date: 2007-07-06
Issue Date: 2011-10-21T02:22:15Z
Publisher: Biochemical and Biophysical Research Communications
Abstract: Abstract:As a safeguard against oxidative stress, the balance between the main antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) was believed to be more important than any single one, for example, dual-functional SOD/CAT enzyme has been proved to have better antioxidant ability than either single enzyme. By combining traditional fusion protein technology with amino acid auxotrophic expression system, we generated a bifunctional enzyme with both GPx and SOD activities. It displayed better antioxidant ability than GPx or SOD. Such dual-functional enzymes could facilitate further studies of the cooperation of GPx and SOD and generation of better therapeutic agents.
Relation: 358(3), pp.873–878
URI: http://ntour.ntou.edu.tw/handle/987654321/27000
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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