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Title: miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines
Authors: Cliff Ji-Fan Lin;Hong-Yi Gong;Hung-Chia Tseng;Wei-Lun Wang;Jen-Leih Wu
Contributors: NTOU:Department of Aquaculture
Keywords: miR-122;Bcl-w;Hepatocellular carcinoma
Date: 2008-10-24
Issue Date: 2011-10-21T02:19:07Z
Publisher: Biochemical and Biophysical Research Communications
Abstract: Abstract:miR-122, a hepato-specific microRNA (miRNA), is frequently down-regulated in human hepatocellular carcinoma (HCC). In an effort to identify novel miR-122 targets, we performed an in silico analysis and detected a putative binding site in the 3′-untranslated region (3′-UTR) of Bcl-w, an anti-apoptotic Bcl-2 family member. In the HCC-derived cell lines, Hep3B and HepG2, we confirmed that miR-122 modulates Bcl-w expression by directly targeting binding site within the 3′-UTR. The cellular mRNA and protein levels of Bcl-w were repressed by elevated levels of miR-122, which subsequently led to reduction of cell viability and activation of caspase-3. Thus, Bcl-w is a direct target of miR-122 that functions as an endogenous apoptosis regulator in these HCC-derived cell lines.
Relation: 375(3), pp.315-320
Appears in Collections:[Department of Aquaculture] Periodical Articles

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