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Title: Antagonizing Effects of Type I Antifreeze Protein on Ca++ Uptake in Fish TO-2 Cells
Authors: Ching-Feng Weng;Hong-Yi Gong;Jen-Leih Wu;Choy-Leong Hew;Pung-Pung Hwang
Contributors: NTOU:Department of Aquaculture
Keywords: Type I antifreeze protein;Ca++ blocker;Ca++ uptake;Ca++ release;Fish cell
Date: 2000
Issue Date: 2011-10-21T02:18:10Z
Publisher: Zoological Studies
Abstract: Abstract:he antifreeze proteins (AFPs) or glycoproteins in several species of polar fish, which prevent the fish from being frozen in icy seawater, have been suggested for use as cryoprotective agents. The present study examines the effect of AFPs on Ca++ flux in a fish TO-2 cell line. The results indicate that type I AFP inhibits the uptake of Ca++ in a dose-dependent manner, but it does not antagonize the release of Ca++. By contrast, type III AFP shows no effect on Ca++ flux. The addition of calcium antagonists, La+++ (LaCl3), Co++ (CoCl2), or verapamil (L-type Ca++ channel blocker), to the uptake medium did not further enhance the blocking effect of AFP on Ca++ uptake, indicating that type I AFP is a non-selective Ca++ blocker.
Relation: 39(2), pp.144-150
URI: http://ntour.ntou.edu.tw/handle/987654321/26648
Appears in Collections:[水產養殖學系] 期刊論文

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