National Taiwan Ocean University Institutional Repository:Item 987654321/23802
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 28603/40634
Visitors : 4392649      Online Users : 425
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search

Please use this identifier to cite or link to this item:

Title: LeeThree-dimensional hydrodynamic focusing with a circular microchannel
Authors: Jyh-Jong Sheen;Huan-Yi Ho;Yao-Min
Contributors: NTOU:Department of Mechanical and Mechatronic Engineering
Date: 2008-06
Issue Date: 2011-10-20T08:08:18Z
Publisher: Proceedings of the Sixth International ASME Conference on Nanochannels, Microchannels and Minichannels, ICNMM2008
Abstract: We propose a simple method to implement three-dimensional (3D) hydrodynamic focusing with a circular micro-channel for the sample flow. We utilized soft lithography technique and a cylindrical object such as an optical fiber to construct a 3D hydrodynamic focusing master mold made of photoresist and the fiber. The 3D microfluidic focusing device can be duplicated by polydimethylsiloxance (PDMS) casting. When peeling the PDMS cast from the master, there is a crack along the circular channel. However, this crack can be recovered from the thermal bonding of the PDMS cast and a PDMS substrate. We applied this technique to fabricate 3D flow-focusing devices for a microfluidic fluorescence detection chip and a micro-emulsion chip. In the case of microfluidic fluorescence detection, the sample flow can form a small and stable cylindrical flow by controlling the flow rates of sheath flow and sample flow. This allows fluorescent particles to be focused at the center of the channel and to be excited uniformly by laser. Experimental results show that the coefficients of variation for 3D hydrodynamic focusing is 4 to 10 times lower than those of 2D hydrodynamic focusing. As a consequence, the 3D focusing chip provides advantages of stable sample flow and highly uniform detection signals. The micro emulsion chip with 3D hydrodynamic focusing can avoid the wetting problem of two immiscible fluids and successfully produce emulsion droplets.
Appears in Collections:[Department of Mechanical and Mechatronic Engineering] Periodical Articles

Files in This Item:

There are no files associated with this item.

All items in NTOUR are protected by copyright, with all rights reserved.


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback